diff --git a/packages/angular/build/src/builders/application/tests/behavior/platform-server-domino_spec.ts b/packages/angular/build/src/builders/application/tests/behavior/platform-server-domino_spec.ts
new file mode 100644
index 000000000000..14d3915e491a
--- /dev/null
+++ b/packages/angular/build/src/builders/application/tests/behavior/platform-server-domino_spec.ts
@@ -0,0 +1,92 @@
+/**
+ * @license
+ * Copyright Google LLC All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.dev/license
+ */
+
+import { buildApplication } from '../../index';
+import { OutputMode, Platform } from '../../schema';
+import { APPLICATION_BUILDER_INFO, BASE_OPTIONS, describeBuilder } from '../setup';
+
+/**
+ * `@angular/platform-server/init` (bundled into the server polyfills) and
+ * `@angular/platform-server` (bundled into the main server bundle) both import this file.
+ */
+const DOMINO_BUNDLE = 'third_party/domino/bundled-domino.mjs';
+
+/** The export of the server polyfills bundle. The output may escape non-ASCII identifiers. */
+const DOMINO_EXPORT = '(?:ɵ|\\\\u0275)domino';
+const POLYFILLS_EXPORT_RE = new RegExp(`export \\{[^}]*${DOMINO_EXPORT}`);
+const MAIN_IMPORT_RE = new RegExp(
+  `import \\{\\s*${DOMINO_EXPORT}\\s*\\} from "\\./polyfills\\.server\\.mjs"`,
+);
+
+describeBuilder(buildApplication, APPLICATION_BUILDER_INFO, (harness) => {
+  describe('Behavior: "Domino is bundled once for the server"', () => {
+    beforeEach(async () => {
+      await harness.modifyFile('src/tsconfig.app.json', (content) => {
+        const tsConfig = JSON.parse(content);
+        tsConfig.files ??= [];
+        tsConfig.files.push('main.server.ts', 'server.ts');
+
+        return JSON.stringify(tsConfig);
+      });
+
+      await harness.writeFile('src/server.ts', `console.log('Hello!');`);
+
+      // The default template uses i18n which requires `@angular/localize` to prerender.
+      await harness.writeFile('src/app/app.component.html', `<p>Hello!</p>`);
+    });
+
+    it('shares the server polyfills copy of Domino with the main server bundle', async () => {
+      harness.useTarget('build', {
+        ...BASE_OPTIONS,
+        server: 'src/main.server.ts',
+        ssr: true,
+      });
+
+      const { result } = await harness.executeOnce();
+      expect(result?.success).toBeTrue();
+
+      harness.expectFile('dist/server/polyfills.server.mjs').content.toContain(DOMINO_BUNDLE);
+      harness.expectFile('dist/server/polyfills.server.mjs').content.toMatch(POLYFILLS_EXPORT_RE);
+
+      harness.expectFile('dist/server/main.server.mjs').content.not.toContain(DOMINO_BUNDLE);
+      harness.expectFile('dist/server/main.server.mjs').content.toMatch(MAIN_IMPORT_RE);
+    });
+
+    it('shares the server polyfills copy of Domino when "outputMode" is "server"', async () => {
+      harness.useTarget('build', {
+        ...BASE_OPTIONS,
+        server: 'src/main.server.ts',
+        ssr: { entry: 'src/server.ts' },
+        outputMode: OutputMode.Server,
+      });
+
+      const { result } = await harness.executeOnce();
+      expect(result?.success).toBeTrue();
+
+      harness.expectFile('dist/server/polyfills.server.mjs').content.toContain(DOMINO_BUNDLE);
+      harness.expectFile('dist/server/main.server.mjs').content.not.toContain(DOMINO_BUNDLE);
+      harness.expectFile('dist/server/main.server.mjs').content.toMatch(MAIN_IMPORT_RE);
+      harness.expectFile('dist/server/server.mjs').content.not.toContain(DOMINO_BUNDLE);
+    });
+
+    it('shares the server polyfills copy of Domino when "ssr.platform" is "neutral"', async () => {
+      harness.useTarget('build', {
+        ...BASE_OPTIONS,
+        server: 'src/main.server.ts',
+        ssr: { entry: 'src/server.ts', platform: Platform.Neutral },
+        outputMode: OutputMode.Server,
+      });
+
+      const { result } = await harness.executeOnce();
+      expect(result?.success).toBeTrue();
+
+      harness.expectFile('dist/server/polyfills.server.mjs').content.toContain(DOMINO_BUNDLE);
+      harness.expectFile('dist/server/main.server.mjs').content.not.toContain(DOMINO_BUNDLE);
+    });
+  });
+});
diff --git a/packages/angular/build/src/tools/esbuild/application-code-bundle.ts b/packages/angular/build/src/tools/esbuild/application-code-bundle.ts
index c98ad3bcae28..e362327848ab 100644
--- a/packages/angular/build/src/tools/esbuild/application-code-bundle.ts
+++ b/packages/angular/build/src/tools/esbuild/application-code-bundle.ts
@@ -6,7 +6,7 @@
  * found in the LICENSE file at https://angular.dev/license
  */
 
-import type { BuildOptions, Plugin } from 'esbuild';
+import type { BuildOptions, Plugin, PluginBuild } from 'esbuild';
 import assert from 'node:assert';
 import { extname, relative } from 'node:path';
 import type { NormalizedApplicationBuildOptions } from '../../builders/application/options';
@@ -30,6 +30,11 @@ import { createExternalPackagesPlugin } from './external-packages-plugin';
 import { createAngularLocaleDataPlugin } from './i18n-locale-plugin';
 import type { LoadResultCache } from './load-result-cache';
 import { createLoaderImportAttributePlugin } from './loader-import-attribute-plugin';
+import {
+  createPlatformServerDominoExport,
+  createPlatformServerDominoPlugin,
+  resolvePlatformServerDomino,
+} from './platform-server-domino-plugin';
 import { createRxjsEsmResolutionPlugin } from './rxjs-esm-resolution-plugin';
 import { createServerBundleMetadata } from './server-bundle-metadata-plugin';
 import { createSourcemapIgnorelistPlugin } from './sourcemap-ignorelist-plugin';
@@ -192,6 +197,13 @@ export function createServerPolyfillBundleOptions(
     namespace,
     false,
     loadResultCache,
+    // Export the Domino copy bundled via `@angular/platform-server/init` so that the other
+    // server bundles can share it instead of bundling their own copy.
+    async (build) => {
+      const dominoPath = await resolvePlatformServerDomino(build, options.workspaceRoot);
+
+      return dominoPath && createPlatformServerDominoExport(dominoPath);
+    },
   );
 
   if (!polyfillBundleOptions) {
@@ -308,6 +320,9 @@ export function createServerMainCodeBundleOptions(
       buildOptions.plugins.push(createRxjsEsmResolutionPlugin());
     }
 
+    // Use the Domino copy exported by the server polyfills bundle instead of bundling another copy.
+    buildOptions.plugins.push(createPlatformServerDominoPlugin(workspaceRoot));
+
     // Mark manifest and polyfills file as external as these are generated by a different bundle step.
     (buildOptions.external ??= []).push(...SERVER_GENERATED_EXTERNALS);
     const isNodePlatform = options.ssrOptions?.platform !== Platform.Neutral;
@@ -677,6 +692,7 @@ function getEsBuildCommonPolyfillsOptions(
   namespace: string,
   tryToResolvePolyfillsAsRelative: boolean,
   loadResultCache: LoadResultCache | undefined,
+  additionalContent?: (build: PluginBuild) => Promise<string | undefined>,
 ): BuildOptions | undefined {
   const { jit, workspaceRoot, i18nOptions, externalPackages } = options;
 
@@ -753,6 +769,11 @@ function getEsBuildCommonPolyfillsOptions(
           contents += `(globalThis.$localize ??= {}).locale = "${i18nOptions.sourceLocale}";\n`;
         }
 
+        const extraContent = await additionalContent?.(build);
+        if (extraContent) {
+          contents += '\n' + extraContent;
+        }
+
         return {
           contents,
           loader: 'js',
diff --git a/packages/angular/build/src/tools/esbuild/platform-server-domino-plugin.ts b/packages/angular/build/src/tools/esbuild/platform-server-domino-plugin.ts
new file mode 100644
index 000000000000..dc060b3cc180
--- /dev/null
+++ b/packages/angular/build/src/tools/esbuild/platform-server-domino-plugin.ts
@@ -0,0 +1,136 @@
+/**
+ * @license
+ * Copyright Google LLC All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.dev/license
+ */
+
+import type { Plugin, PluginBuild } from 'esbuild';
+import { access } from 'node:fs/promises';
+import { dirname, join, resolve } from 'node:path';
+import { toPosixPath } from '../../utils/path';
+
+/**
+ * The name of the export in the server polyfills bundle that provides the Domino DOM
+ * implementation to the other server bundles.
+ */
+const SERVER_POLYFILLS_DOMINO_EXPORT = 'ɵdomino';
+
+/**
+ * The server polyfills bundle filename. Other server bundles import Domino from this file.
+ */
+const SERVER_POLYFILLS_FILENAME = './polyfills.server.mjs';
+
+/**
+ * The path of the Domino bundle within the `@angular/platform-server` package.
+ * `@angular/platform-server/init` and `@angular/platform-server` both import this file.
+ */
+const DOMINO_PACKAGE_PATH = 'third_party/domino/bundled-domino.mjs';
+
+/**
+ * The import specifier used by the `@angular/platform-server` entry points to import Domino.
+ */
+const DOMINO_IMPORT_SPECIFIER = '../' + DOMINO_PACKAGE_PATH;
+
+const DOMINO_NAMESPACE = 'angular:platform-server-domino';
+
+/**
+ * Resolves the path of the Domino bundle within the `@angular/platform-server` package
+ * that is used by the application.
+ *
+ * `@angular/platform-server/init` (bundled into the server polyfills) and
+ * `@angular/platform-server` (bundled into the main server bundle) both contain a copy of
+ * Domino when bundled separately. The server polyfills bundle exports its copy via
+ * `SERVER_POLYFILLS_DOMINO_EXPORT` so that the other server bundles can share it instead of
+ * bundling their own.
+ *
+ * @param build The esbuild plugin build used to resolve the package.
+ * @param workspaceRoot The root directory of the workspace.
+ * @returns The absolute path to the Domino bundle, or `undefined` if it cannot be shared.
+ */
+export async function resolvePlatformServerDomino(
+  build: PluginBuild,
+  workspaceRoot: string,
+): Promise<string | undefined> {
+  const result = await build.resolve('@angular/platform-server/package.json', {
+    kind: 'import-statement',
+    resolveDir: workspaceRoot,
+  });
+
+  // The package is not installed or will not be bundled.
+  if (result.errors.length > 0 || result.external || !result.path) {
+    return undefined;
+  }
+
+  const dominoPath = join(dirname(result.path), DOMINO_PACKAGE_PATH);
+  try {
+    await access(dominoPath);
+  } catch {
+    // Unexpected package layout. Each bundle will contain its own copy of Domino.
+    return undefined;
+  }
+
+  return dominoPath;
+}
+
+/**
+ * Creates the module content that re-exports Domino from the server polyfills bundle.
+ *
+ * @param dominoPath The absolute path to the Domino bundle.
+ * @returns The module content.
+ */
+export function createPlatformServerDominoExport(dominoPath: string): string {
+  const specifier = JSON.stringify(toPosixPath(dominoPath));
+
+  return `export { default as ${SERVER_POLYFILLS_DOMINO_EXPORT} } from ${specifier};`;
+}
+
+/**
+ * Creates a plugin that redirects the Domino import of `@angular/platform-server` to the
+ * copy exported by the server polyfills bundle.
+ *
+ * The server polyfills bundle is imported by every server bundle before any other code and
+ * is marked as external. This ensures a single copy of Domino is loaded at runtime, which
+ * also keeps the DOM globals provided by `@angular/platform-server/init` consistent with the
+ * DOM implementation used by the server platform.
+ *
+ * @param workspaceRoot The root directory of the workspace.
+ * @returns An esbuild plugin.
+ */
+export function createPlatformServerDominoPlugin(workspaceRoot: string): Plugin {
+  return {
+    name: 'angular-platform-server-domino',
+    setup(build) {
+      let sharedDominoPath: Promise<string | undefined> | undefined;
+
+      build.onResolve({ filter: /bundled-domino\.mjs$/ }, async (args) => {
+        if (args.path !== DOMINO_IMPORT_SPECIFIER || args.kind !== 'import-statement') {
+          return null;
+        }
+
+        sharedDominoPath ??= resolvePlatformServerDomino(build, workspaceRoot);
+        const dominoPath = await sharedDominoPath;
+
+        // Only redirect imports of the exact file exported by the server polyfills bundle.
+        if (!dominoPath || resolve(args.resolveDir, args.path) !== dominoPath) {
+          return null;
+        }
+
+        // The path must not look like a JavaScript file to avoid other plugins loading it.
+        return {
+          path: DOMINO_NAMESPACE,
+          namespace: DOMINO_NAMESPACE,
+        };
+      });
+
+      build.onLoad({ filter: /./, namespace: DOMINO_NAMESPACE }, () => ({
+        contents:
+          `export { ${SERVER_POLYFILLS_DOMINO_EXPORT} as default } ` +
+          `from '${SERVER_POLYFILLS_FILENAME}';`,
+        loader: 'js',
+        resolveDir: workspaceRoot,
+      }));
+    },
+  };
+}